Herbal Interactions

Burdock

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking burdock if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Bleeding disorders: Burdock might slow blood clotting. Taking burdock might increase the risk of bleeding in people with bleeding disorders.

Allergy to ragweed and related plants: Burdock may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking burdock.

Diabetes: Some evidence suggests that taking burdock might lower blood sugar levels. Taking burdock might lower blood sugar levels too much in people with diabetes who are already taking medications to lower blood sugar.

Surgery: Burdock might increase the risk of bleeding during and after surgery. Stop taking it at least 2 weeks before a scheduled surgery.

Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Burdock might decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking burdock along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBetaGlynase PresTabMicronase), insulinpioglitazone (Actos), rosiglitazone (Avandia),

DEVILS CLAW

Devil’s claw is a flowering plant of the sesame family. Its root packs several active plant compounds and is used as an herbal supplement.

In particular, devil’s claw contains iridoid glycosides, a class of compounds which has demonstrated anti-inflammatory effects (2Trusted Source).

Some but not all studies suggest that iridoid glycosides may also have antioxidant effects. This means the plant may have the ability to ward off cell-damaging effects of unstable molecules called free radicals (34Trusted Source5Trusted Source).

For these reasons, devil’s claw supplements have been studied as a potential remedy for inflammatory-related conditions, such as arthritis and gout. In addition, it has been proposed to reduce pain and may support weight loss.

Devil’s claw appears to be safe when taken in doses up to 2,610 mg daily, though long-term effects have not been investigated (29).

Reported side effects are mild, the most common being diarrhea. Rarer adverse effects include allergic reactions, headache and coughing (30Trusted Source).

However, some conditions may put you at a higher risk for more serious reactions (31):

  • Heart disorders: Studies have indicated that devil’s claw can affect heart rate, heartbeat and blood pressure.
  • Diabetes: Devil’s claw may reduce blood sugar levels and intensify the effects of diabetes medications.
  • Gallstones: Use of devil’s claw may increase the formation of bile and make problems worse for those with gallstones.
  • Stomach ulcers: Production of acid in the stomach can increase with the use of devil’s claw, which may aggravate peptic ulcers.

Common medications may also negatively interact with devil’s claw, including prescription nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners and stomach acid reducers (31):

  • NSAIDs: Devil’s claw may slow the absorption of popular NSAIDs, such as Motrin, Celebrex, Feldene and Voltaren.
  • Blood thinners: Devil’s claw may enhance the effects of Coumadin (also known as warfarin), which may lead to increased bleeding and bruising.
  • Stomach acid reducers: Devil’s claw may decrease the effects of stomach acid reducers, such as Pepcid, Zantac, Prilosec and Prevacid.

Drug Interactions

  • Allegra (fexofenadine)
  • Celebrex (celecoxib)
  • Coumadin (warfarin)
  • Cozaar (losartan)
  • Elavil (amitriptyline)
  • Feldene (piroxicam)
  • Glucotrol (glipizide)
  • Halcion (triazolam)
  • Mevacor (lovastatin)
  • Mobic (meloxicam)
  • Motrin (ibuprofen)
  • Nizoral (ketoconazole)
  • Prevacid (lansoprazole)
  • Prilosec (omeprazole)
  • Protonix (pantoprazole)
  • Soma (carisoprodol)
  • Sporanox (itraconazole)
  • Valium (diazepam)
  • Viracept (nelfinavir)
  • Voltaren (diclofenac)

(https://www.healthline.com/nutrition/devils-claw#what-it-is )

Rosemary

Rosemary can affect the activity of some medications, including: Anticoagulant drugs: These include blood-thinning medications, such as Warfarin, Aspirin, and Clopidogrel. … Rosemary can act as a diuretic and cause lithium to reach toxic levels in the body

HEMP

Do not ingest hemp when taking:

  • Cardiac glycosides, such as Lanoxin (digoxin): These medications help the heart beat strongly and can slow down the heart rate. Hemp is also known to slow the heart rate; this could result in bradycardia. Do not take hemp when taking Lanoxin without consulting with the prescribing physician or another healthcare provider.
  • Diuretics: Including such as Diuril (chlorothiazide), Thalitone (chlorthalidone), Lasix (furosemide), Microzide (hydrochlorothiazide) and others. Diuretics may lower potassium in the body as they work to flush fluids. Hemp has a similar action. When there is an increase in urine/fluid output, it’s common that potassium is also lost. Taking diuretics and hemp together may result in dangerously low potassium levels which could adversely impact the heart.

According to RX List, taking whole hemp by mouth can cause many side effects including:

  • Throat irritation
  • Diarrhea
  • Nausea and vomiting
  • Bradycardia (slow heart rate)
  • Hypertension (high blood pressure)

ALOE VERA


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WHAT OTHER NAMES IS ALOE KNOWN BY?

Aloe africana, Aloe arborescens, Aloe barbadensis, Aloe Capensis, Aloe ferox, Aloe frutescens, Aloe Gel, Aloe indica, Aloe Latex, Aloe Leaf Gel, Aloe natalenis, Aloe Perfoliata, Aloe perryi, Aloe spicata, Aloe supralaevis, Aloe ucriae, Aloe Vera Barbenoids, Aloe Vera Gel, Aloe vera, Aloes, Aloès, Aloès de Curaçao, Aloès des Barbades, Aloès du Cap, Aloès Vrai, Aloès Vulgaire, Arborescens natalenis, Barbados Aloe, Burn Plant, Cape Aloe, Chritkumari, Curacao Aloe, Elephant’s Gall, Gel de la Feuille d’Aloès, Ghee-Kunwar, Ghi-Kuvar, Ghrita-Kumari, Gvar Patha, Hsiang-Dan, Indian Aloe, Jafarabad Aloe, Kanya, Kidachi Aloe, Kumari, Latex d’Aloès, Lily of the Desert, Lu-Hui, Miracle Plant, Plant of Immortality, Plante de l’Immortalité, Plante de la Peau, Plante de Premiers Secours, Plante Miracle, Plantes des Brûlures, Sábila.

WHAT IS ALOE?

Aloe is a cactus-like plant that grows in hot, dry climates. In the United States, aloe is grown in Florida, Texas, and Arizona. Aloe produces two substances, gel and latex, which are used for medicines. Aloe gel is the clear, jelly-like substance found in the inner part of the aloe plant leaf. Aloe latex comes from just under the plant’s skin and is yellow in color. Some aloe products are made from the whole crushed leaf, so they contain both gel and latex. The aloe that is mentioned in the Bible is an unrelated fragrant wood used as incense.

Aloe medications can be taken by mouth or applied to the skin. People take aloe gel by mouth for weight lossdiabeteshepatitis, inflammatory bowel diseases, osteoarthritisstomach ulcers, asthmaradiation-related skin sores, feveritching and inflammation, and as a general tonic. A chemical in aloe called acemannan is taken by mouth for HIV/AIDS. Aloe extract is used for high cholesterol.

Aloe latex is taken by mouth mainly as a laxative for constipation. It is also used for seizures, asthma, colds, bleeding, lack of a menstrual period, swelling of the colon (colitis), depression, diabetes, eye conditions that cause blindness (glaucoma), multiple sclerosishemorrhoidsvaricose veinsjoint inflammation, osteoarthritis, and vision problems. Fresh aloe leaves are taken by mouth for cancer.

People apply aloe gel to the skin for acne, an inflammatory skin condition called lichen planus, inflammation in the mouth, burning mouth, radiation-induced skin damage, dental plaquediaper rashfrostbitegum disease, bedsores, scabiesdandruff, wound healing, hemorrhoids and pain after surgery to remove internal hemorrhoids, osteoarthritis, inflammation, and as an antiseptic. Aloe extract and aloe gel are also applied to the skin for genital herpes, scaly and itchy skin, burns, sunburns, and dry skin. Aloe extract is applied to the skin as an insect repellant. Aloe leaf juice is applied to the skin for anal fissures. A chemical in aloe called acemannan is applied to the skin for dry sockets in the mouth and canker sores.

IS ALOE EFFECTIVE?

There is some scientific evidence that aloe gel might help when used on the skin for reducing the pain and swelling of burns, to speed the healing of burns, and for skin sores, psoriasis, and frostbite.

There isn’t enough information to know if aloe gel is effective for the other conditions people use it for, including: arthritis, fever, itching, stomach ulcers, diabetes, and asthma.

POSSIBLY EFFECTIVE FOR…

  • Acne. Research suggests that applying an aloe gel in the morning and evening, in addition to a prescription anti-acne medicine, improves acne by about 35% in both children and adults.
  • Burns. Applying aloe gel to the skin seems to improve burn healing. Also applying cream that contains aloe to the skin twice daily appears to improve itching and reduce skin picking compared to applying corticosteroid medication in people with chemical burns. It is unclear if aloe reduces healing time compared to applying antibiotics. Some research shows that applying aloe cream reduces healing time and wound size compared to applying antibiotics in people with first or second degree burns. But other early research suggests that applying fresh aloe or aloe extract daily is not more effective than antibiotic treatments for reducing wounds or improving healing in people with first or second degree burns.
  • Constipation. Taking aloe latex by mouth can reduce constipation and also cause diarrhea.
  • Genital herpes. Evidence shows that applying an aloe extract 0.5% cream three times daily increases healing rates in men with genital herpes.
  • Itchy rash on the skin or mouth (Lichen planus). Research shows that using a mouthwash containing aloe gel three times daily for 12 weeks or applying a gel containing aloe gel twice daily for 8 weeks can reduce pain associated with itchy rashes in the mouth. Other research shows that using a mouthwash containing aloe four times daily for one month or applying an aloe gel three times daily for 2 months reduces pain and increases healing similarly to the corticosteroid triamcinolone acetonide in people with itchy rashes in the mouth.
  • A mouth condition called oral submucous fibrosis. Early research suggests that applying aloe gel (Sheetal lab Surat) on each side of the inner lining of the cheeks three times daily for 3 months improves burning, the ability to open the mouth, and cheek flexibility in people with a mouth condition called oral submucous fibrosis. Other research suggests that applying aloe gel twice daily for up to 6 months along with other treatments can reduce burning and improve movement of the mouth.
  • Psoriasis. Applying a cream containing 0.5% aloe extract for 4 weeks seems to reduce the skin plaques. Also applying cream containing aloe gel seems to decrease the severity of psoriasis better than the corticosteroid triamcinolone. But using an aloe gel does not seem to improve other symptoms associated with psoriasis, including skin redness.
  • Weight loss. Research suggests that taking a specific aloe product (Aloe QDM complex, Univera Inc., Seoul, South Korea) containing 147 mg of aloe gel twice daily for 8 weeks reduces body weight and fat mass in overweight or obese people with diabetes or prediabetes.

HOW DOES ALOE WORK?

The useful parts of aloe are the gel and latex. The gel is obtained from the cells in the center of the leaf; and the latex is obtained from the cells just beneath the leaf skin.

Aloe gel might cause changes in the skin that might help diseases like psoriasis.

Aloe seems to be able to speed wound healing by improving blood circulation through the area and preventing cell death around a wound.

It also appears that aloe gel has properties that are harmful to certain types of bacteria and fungi.

Aloe latex contains chemicals that work as a laxative.

ARE THERE SAFETY CONCERNS?

Aloe gel is LIKELY SAFE when applied to the skin appropriately as a medicine or as a cosmetic.

Aloe gel is POSSIBLY SAFE when taken by mouth appropriately, short-term. Aloe gel has been used safely in a dose of 15 mL daily for up to 42 days. Also, a solution containing 50% aloe gel has been safely used twice daily for 4 weeks. A specific gel complex (Aloe QDM complex Univera Inc., Seoul, South Korea) has been used safely at a dose of about 600 mg daily for up to 8 weeks.

Taking aloe latex or aloe whole-leaf extract by mouth is POSSIBLY UNSAFE at any dose. Aloe latex is LIKELY UNSAFE when taken by mouth in high doses. Aloe latex can cause some side effects such as stomach pain and cramps. Long-term use of large amounts of aloe latex might cause diarrhea, kidney problems, blood in the urine, low potassiummuscle weakness, weight loss, and heart disturbances. Taking aloe latex 1 gram daily for several days can be fatal. Also, there is concern that chemicals in aloe latex and/or aloe whole-leaf extract may promote the development of cancer.

There have been a few reports of liver problems in some people who have taken an aloe leaf extract; however, this is uncommon. It is thought to only occur in people who are extra sensitive (hypersensitive) to aloe.

Special Precautions & Warnings:

Pregnancy or breast-feeding: Aloe — either gel or latex — is POSSIBLY UNSAFE when taken by mouth. There is a report that aloe was associated with miscarriage. It could also be a risk for birth defects. Do not take aloe by mouth if you are pregnant or breast-feeding.

ARE THERE ANY INTERACTIONS WITH MEDICATIONS?


Digoxin (Lanoxin)Interaction Rating: Major Do not take this combination.

When taken by mouth, aloe latex is a type of laxative called a stimulant laxative. Stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin).


Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Aloe gel might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking aloe gel along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBetaGlynase PresTabMicronase), insulinmetformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.


Medications taken by mouth (Oral drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

When taken by mouth, aloe latex is a laxative. Laxatives can decrease how much medicine your body absorbs. Taking aloe latex along with medications you take by mouth might decrease the effectiveness of your medication.


Sevoflurane (Ultane)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Aloe might decrease clotting of the blood. Sevoflurane is used as anesthesia during surgery. Sevoflurane also decreases clotting of the blood. Taking aloe before surgery might cause increased bleeding during the surgical procedure. Do not take aloe by mouth if you are having surgery within 2 weeks.


Stimulant laxativesInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

When taken orally, aloe latex is a type of laxative called a stimulant laxative. Stimulant laxatives speed up the bowels. Taking aloe latex along with other stimulant laxatives could speed up the bowels too much and cause dehydration and low minerals in the body.

Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others.


Warfarin (Coumadin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

When taken orally, aloe latex is a type of laxative called a stimulant laxative. Stimulant laxatives speed up the bowels and can cause diarrhea in some people. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. If you take warfarin, do not take excessive amounts of aloe latex.


Water pills (Diuretic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

When taken by mouth, aloe latex is a laxative. Some laxatives can decrease potassium in the body. “Water pills” can also decrease potassium in the body. Taking aloe latex along with “water pills” might decrease potassium in the body too much.

Some “water pills” that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others.